Sean Murphy homered, Sean Manaea received backing from his defense and the Oakland Athletics rebuilt the road a day after breaking a 13-game win streak by defeating the Rays 2-1 on Monday from Tampa Bay.
After what Matt Chapman traded a two-out walk in the fourth off Rich Hill (1-1), Murphy made it 2-1 with his plank to left field.
Manaea (3-1) threw 100 pitches in five innings, in which he allowed one run and four hits.
Yusmeiro Petit worked two innings in order, Jake Diekman escaped a situation with runners on second and third with one out in the eighth and Lou Trivino dropped the curtain for his third save.
Oakland, which lost 8-1 to Baltimore on Sunday, is 15-2 in their last 17 games after starting the season with a 0-6 record.
Hill struck out 10 enemies in six innings, in which he conceded only two indisputable ones.
For the Athletics, the Dominican Ramón Laureano 4-1 and Venezuelan Elvis Andrus 2-0.
For the Rays, the Cubans Randy Arozarena 4-3 with a run scored; Yandy Diaz 2-0. The Dominicans Manuel Margot 4-1, Willy Adames 3-0 and Francisco Mejía 2-0.