Lyou Colorado Rockies beat Jake Arrieta, who also left injured from the game that marked his debut with the Padres San Diego, defeated 7-5 on Wednesday.
CJ Cron had two hits and three runs, while Trevor Story homered for the Rockies, who scored five runs in 3 1/3 innings off Arrieta. before he left with a left hamstring condition.
Arrieta (5-12) came to the Padres on Monday after being released by the Chicago Cubs. He allowed seven hits and allowed his ERA to deteriorate to 7.13 as he received a solo homer from Dom Nunez before grabbing his thigh and leaving the game.
Wil Myers hit a pair of home runs for ailing San Diego. The Padres have lost seven of eight games but still have a game-and-a-half advantage over Cincinnati in the bid for the second wild-card spot to the National League playoffs.
The Rockies took a 3-0 lead in the first inning, thanks to a two-run double by Cron and a single by Ryan McMahon.
Ben Bowden (2-2) allowed one run in one inning. Daniel Bard resolved the ninth for his 20th save in 26 chances.
For the Fathers, the Dominicans Fernando Tatis 4-0, Machado 5-1 with a push.
For the Rockies, Venezuelan Carlos González 1-0.